Formulation development of a live attenuated human rotavirus (RV3-BB) vaccine candidate for use in low- and middle-income countries

Human neonatal rotavirus vaccine (RV3-BB) targets rotavirus from birth

BACKGROUND A strategy of administering a neonatal rotavirus vaccine at birth to target early prevention of rotavirus gastroenteritis may address some of the barriers to global implementation of a rotavirus vaccine. METHODS We conducted a randomized, double-blind, placebo-controlled trial in Indonesia to evaluate the efficacy of an oral human neonatal rotavirus vaccine (RV3-BB) in preventing r...

Development of a New Live Attenuated Mumps Virus Vaccine in Human Deploid Cells

RIX4414 (Rotarix): a live attenuated human rotavirus vaccine.

report. New York: Oxford University; 2005. 4. Fortes Filho JB, Barros CK, daCostaMC, ProcianoyRS. Results of a program for the prevention of blindness caused by retinopathy of prematurity in southern Brazil. J Pediatr (Rio J). 2007;83:209-16. 5. Gilbert C, Fielder F, Gordillo L, Quinn G, Semiglia R, Visintin P, et al. Characteristics of infants with severe retinopathy of prematurity in countrie...

Balancing safety, efficacy and cost: Improving rotavirus vaccine adoption in low- and middle-income countries

Just over a decade ago, concerns regarding vaccine-related risks led to the demise of the first rotavirus vaccine to enter the market. Licensed in the US in 1998, RotaShield was withdrawn voluntarily in 1999 by its manufacturer, Wyeth, when it was found to be associated with an increased risk of intussusception, a potentially serious and occasionally fatal intestinal obstruction estimated to oc...

Measuring indirect effects of rotavirus vaccine in low income countries

Widespread introduction of rotavirus vaccines has led to major reductions in the burden of rotavirus gastroenteritis worldwide. Vaccine effectiveness is diminished, however, in low income countries, that harbour the greatest burden of rotavirus attributed morbidity and mortality. Indirect effects of rotavirus vaccine (herd immunity and herd protection) could increase population level impact and...